General Information

  • ID:  hor005298
  • Uniprot ID:  P29206
  • Protein name:  Peptide YY-like (PYY)
  • Gene name:  NA
  • Organism:  Beringraja rhina (Longnose skate) (Raja rhina)
  • Family:  NPY family
  • Source:  animal
  • Expression:  pancreas
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Beringraja (genus), Rajidae (family), Rajiformes (order), Batoidea (superorder), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YPPKPENPGDDAAPEELAKYYSALRHYINLITRQRY
  • Length:  36
  • Propeptide:  YPPKPENPGDDAAPEELAKYYSALRHYINLITRQRY
  • Signal peptide:  NA
  • Modification:  T36 Tyrosine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P29206-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P29206-F1.pdbhor005298_AF2.pdbhor005298_ESM.pdb

Physical Information

Mass: 487520 Formula: C193H290N52O57
Absent amino acids: CFMVW Common amino acids: PY
pI: 7.51 Basic residues: 6
Polar residues: 10 Hydrophobic residues: 9
Hydrophobicity: -114.72 Boman Index: -9110
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 65.28
Instability Index: 6925.56 Extinction Coefficient cystines: 7450
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  2067973
  • Title:  Neuropeptide Y-related peptides from the pancreas of a teleostean (eel), holostean (bowfin) and elasmobranch (skate) fish.